Lloyds Bank is shutting its branch at Five Oaks by the end of the year, with 18 jobs being lost.
The bank has also announced plans to close its premises in Alderney and Guernsey.
In total, 34 jobs are being lost across the Channel Islands and Isle of Man.
The company says it will try to find new jobs for affected staff wherever possible.
Lloyds' branches at Broad Street and Les Quennevais will remain open.
Director Alasdair Gardner said it follows a 'significant reduction' in customers visiting over the last 10 years, with more of us banking online:
"Our Five Oaks branch in Jersey will close later on this year in response to the significant reduction in customers using this branch over the last ten years. Our customers have more choice than ever in how they bank with us with many carrying out their everyday banking online.
We continue to invest in our branches, as seen with the refurbishment of the Lloyds Bank in Broad Street. We have two branches in Jersey at 8 Broad Street, St Helier and La Route Des Quennevais, St Brelade, which are a short drive away and also accessible by public transport and customers can also continue to use nearby free-to-use ATMs."