Direct flights to the Italian city will launch on 12 April.
More than a thousand islanders voted as part of Aurigny's destination survey.
Every Saturday for a month, holidaymakers can fly direct between Guernsey and Genoa.
Chief Commercial Officer at Aurigny, Sudeep Ghai, says the city has much to offer.
'Genoa offers a mix of culture, food, and sun, just in time for Easter.
'We’ve carefully crafted our seasonal schedule this year to offer our community direct connectivity to exciting destinations across Europe while continuing to safeguard the vital lifeline services to the UK that our customers rely on.'
Flights run until 10 May and start from £149.99 one way.
Merrien bags silver for Guernsey in Glasgow
Guernsey Scarecrow Festival raises bumper amount
Guernsey athlete has Commonwealth Games medal hopes dashed
Guernsey Prison to explore use of temporary officers
Guernsey to have 250 homes under development by 2029
Petition calls for more parent-child parking in Guernsey
Guernsey's Chalmers makes the Commonwealth Games final
More than 40% of Guernsey people surveyed have no savings
