Salah suffered shoulder ligament damage playing for Liverpool in the Champions League final last month following a challenge from Real Madrid defender Sergio Ramos and has not played since.
But when asked about Salah’s potential involvement against Uruguay, Cuper said: “We still have to see how training goes today, but I can almost assure you 100 per cent that he will play – save unforeseen circumstances at the very last minute.
“We are all very optimistic that he will be on the pitch.”
Cuper added: “Nothing prevents him from competing for the title of the golden boot.”
Salah’s involvement from the beginning of the tournament would be a huge boost to his country in their first World Cup in 28 years. The 25-year-old scored 44 goals for Liverpool this season.
Following their match against Uruguay, Egypt face hosts Russia and Saudi Arabia in Group A.